This volume consitutes selected papers presented during the First Pan-African Conference on Artificial Intelligence, PanAfriCon AI 2022, held in Addis Ababa, Ethiopia, in October 2022. The 16 papers were thoroughly reviewed and selected from the 49 qualified submissions. The papers are organized in the following topical sections: ​AI in public health; agriculture; algorithmic optimization; human-machine interaction; economy and security.